As of 10-15 years ago, canine lymphoma was primarily considered to be a monolithic disease with two main subtypes – high grade B-cell and T-cell lymphoma. In veterinary school, it was taught that “B is bad, but T is terrible.” Over time, this view has changed. Diffuse large B-cell lymphoma and peripheral T-cell lymphoma remain the two predominant subtypes, but we’ve come to recognize a population of more indolent lymphoid malignancies that share a slower clinical course.